Effects of buprenorphine versus buprenorphine/naloxone
tablets in non-dependent opioid abusers

Strain EC, Stoller K, Walsh SL, Bigelow GE
Department of Psychiatry and Behavioral Sciences,
The Johns Hopkins University School of Medicine,
Baltimore, MD 21224, USA.
Psychopharmacology (Berl) 2000 Mar;148(4):374-83


RATIONALE: Buprenorphine is an opioid agonist-antagonist under development in the United States as a sublingual medication for treatment of opioid dependence. Buprenorphine may be abused; therefore, tablets combining buprenorphine with naloxone have been developed with the intent of reducing the abuse risk in people physically dependent upon opioids. The characteristics and abuse potential of buprenorphine and buprenorphine/naloxone tablets in non-dependent opioid abusers have not been determined. Non-parenteral abuse of opioids such as buprenorphine may be more likely in people who have less severe substance abuse disorders (e.g., are not physically dependent upon opioids). OBJECTIVES: To assess the abuse potential of sublingual buprenorphine and buprenorphine/naloxone tablets in non-dependent opioid abusers. METHODS: Subjects (n=7) were tested with sublingual buprenorphine (4, 8, 16 mg), sublingual buprenorphine/naloxone (1/0.25, 2/0.5, 4/1, 8/2, 16/4 mg), as well as intramuscular hydromorphone as an opioid agonist control (2, 4 mg) and placebo in laboratory sessions conducted twice per week. Dosing was double-blind and double-dummy. RESULTS: The higher doses of both buprenorphine and buprenorphine/naloxone produced similar opioid agonist-like effects. The onset of these effects was slowed, consistent with the sublingual route of administration, and the magnitude of effects was moderate. There was no evidence to suggest the addition of naloxone attenuated buprenorphine's opioid agonist effects in this population when buprenorphine was delivered by the sublingual route. CONCLUSIONS: These results suggest that sublingual buprenorphine and buprenorphine/naloxone may both be abused by opioid users who are not physically dependent upon opioids.
Quality of life
LAAM v Methadone
Subutex and Suboxone
Opioids and depression
Transdermal buprenorphine
Buprenorphine and reward
Buprenorphine plus naloxone
Buprenorphine and naltrexone
Buprenorphine and the receptors
Buprenorphine for speedball users
Buprenorphine as an antidepressant
Buprenorphine: the standard wisdom
Buprenorphine versus methadone or placebo

and further reading

Future Opioids
BLTC Research
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Good Drug Guide

The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family