Induction of withdrawal-like symptoms in a small randomized,
controlled trial of opioid blockade in frequent tanners

Kaur M, Liguori A, Lang W, Rapp SR, Fleischer AB Jr, Feldman SR.
Center for Dermatology Research, Department of Dermatology,
Wake Forest University School of Medicine, Winston-Salem,
North Carolina 27157-1071, USA.
J Am Acad Dermatol. 2006 Apr;54(4):709-11.


Frequent tanning has reinforcing properties. We tested whether opioid antagonism blocks potential reinforcing effect of indoor tanning in 8 frequent tanners and 8 infrequent tanner control subjects. Opioid blockade reduced ultraviolet preference in frequent tanners. Four of 8 frequent tanners, but no infrequent tanners, exhibited withdrawal-like symptoms with naltrexone administration. A limitation of this study is its small size.
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