Morphine upregulates functional expression
of neurokinin-1 receptor in neurons

by
Wan Q, Douglas SD, Wang X, Kolson DL, O'donnell LA, Ho WZ.
Division of Allergy and Immunology, Joseph Stokes Jr.
Research Institute at The Children's Hospital of Philadelphia,
Department of Pediatrics,
Philadelphia, Pennsylvania.
J Neurosci Res. 2006 Sep 18;


ABSTRACT

Neuronkinin-1 receptor (NK-1R), the neuropeptide substance P (SP) preferring receptor, is highly expressed in areas of the central nervous system (CNS) that are especially implicated in depression, anxiety, and stress. Repeated exposure to opioids may sensitize neuronal systems involved in stress response. We examined the effects of morphine, the principal metabolite of heroin, on the functional expression of NK-1R in the cortical neurons. NK-1R and mu-opioid receptor (MOR) are co-expressed in the cortical neurons. Morphine enhanced NK-1R expression in the cortical neurons at both the mRNA and protein levels. The upregulated NK-1R by morphine had functional activity, because morphine-treated cortical neurons had greater SP-induced Ca(2+) mobilization than untreated neurons. Blocking opioid receptors on the cortical neurons by naltrexone or CTAP (a mu-opioid receptor antagonist) abolished the morphine action. Investigation of the mechanism(s) responsible for the morphine action showed that morphine activated NK-1R promoter and induced the phosphorylation of p38 MAPK protein in the cortical neurons. These in vitro data provide a plausible cellular mechanism for opioid-mediated neurological disorders
Morphine
Tolerance
Dependence
Morphine: structure
Morphine biosynthesis?
Morphine and serotonin
Opioids, mood and cognition
Morphine as an antipsychotic?
Is morphine an antidepressant?
Depression, opioids and the HPA
Methadone, morphine and heroin
Morphine for endogenous depressives
Methadone and morphine as antidepressants
Opioids, depression and learned helplessness
The detection of morphine and codeine in human teeth
Morphine stops long-term potentiation at inhibitory synapses
Use of oxycodone and oxymorphone to treat major depression
Kappa opioid antagonists as antidepressants : norbinaltorphimine


Refs
and further reading

HOME
HedWeb
Nootropics
cocaine.wiki
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Good Drug Guide

The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family