Morphine, the Proteus
of organic molecules
by
Blakemore PR, White JD.
School of Chemistry,
University of Leeds,
Leeds, UK LS2 9JT.
Chem Commun (Camb). 2002 Jun 7;(11):1159-68.

ABSTRACT

Phis feature article encapsulates the senior author's longstanding interests in opiate chemistry and attempts to place it within an historical context and against the backdrop of related work by others who have viewed morphine as one of the pinnacles of natural product synthesis. Biomimetic and 'bioanalogous' routes to the morphine skeleton are discussed followed by approaches based on the elaboration of phenanthrene platforms. The latter include an asymmetric synthesis of ent-morphine developed in our laboratory.

Mu3
fMRI
Morphine
Dependence
Zero tolerance?
Wilhelm Sertürner
Morphine in amygdala
Is morphine a smart drug?
Opioids, mood and cognition
Is morphine an antidepressant?
Morphine directly inhibits nociceptors in inflamed skin


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