Advancement of opioid analgesia
with controlled-release oxycodone

Levy MH.
Department of Medical Oncology,
Fox Chase Cancer Center,
Philadelphia, PA, USA.
Eur J Pain 2001;5 Suppl A:113-6


Optimal pharmacologic management of pain requires selection of the appropriate analgesic drug, prescription of the appropriate dose, administration of the analgesic by the appropriate route, scheduling of the appropriate dosing interval, prevention of persistent pain and relief of breakthrough pain, aggressive titration of the dose of the analgesic, prevention, anticipation, and management of analgesic side-effects, use of appropriate co-analgesic drugs, and consideration of sequential trials of opioid analgesics. Controlled-release oxycodone (CRO) has the characteristics of an 'ideal' opioid analgesic drug: short half-life, long duration of action, predictable pharmacokinetics, absence of clinically active metabolites, rapid onset of action, easy titration, no ceiling dose, minimal adverse effects, and minimal associated stigma. CRO has been shown to be effective in the control of pain caused by cancer, osteoarthritis, post-herpetic neuralgia, major surgery, and degenerative spine disease.
Oxycontin use
'Hillbilly heroin'?
The OxyCon Game
The Oxycontin Doctor
Oxycodone: structure
Oxycodone: metabolism
Tramadol versus oxycodone
Oxycodone versus morphine
Oxycodone: pharmacokinetics
Oxycodone controlled-release
Oxycontin: politics and science
OxyContin: prescribing indications

and further reading

Future Opioids
BLTC Research
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Good Drug Guide

The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family